Kdigo guidelines steroid resistant nephrotic syndrome

Endocrine Treatment of Transsexual Persons
Last updated :         2009
Published :             J Clin Endocrinol Metab   2009; 94:3132–3154
Sponsor:               Endocrine Society, European Society of Endocrinology, European Society for Paediatric Endocrinology, Lawson Wilkins Pediatric Endocrine Society, and World Professional Association for Transgender Health
Website :              http://-/guidelines/Current-Clinical-Practice-

Transplant centers should be notified before attempts to conceive; this allows for evaluation of graft function and adjustment of immunosuppressive regimens, if needed. Ideally, patients should not have experienced graft rejection within the past year; should have stable graft function, no acute infections, and controlled comorbidities; and should be on a stable immunosuppressive regimen before conceiving. 4 , 7 , 19 Certain immunosuppressive agents should be discontinued before pregnancy because of the increased risk of fetal compromise. Mycophenolic acid compounds have about a 25% risk of birth defects, and mammalian target of rapamycin inhibitors increase the risk of preterm delivery, decreased fetal weight, and delayed skeletal ossification. 7 , 19 , 23 Azathioprine, cyclosporine (Sandimmune), and tacrolimus (Prograf) have not been shown to increase the risk of birth defects. 19

Results  Treatment with paricalcitol reduced parathyroid hormone levels within 4 weeks and maintained levels within the normal range throughout the study duration. At 48 weeks, the change in left ventricular mass index did not differ between treatment groups (paricalcitol group, g/m [95% CI, − to g/m ] vs placebo group, − g/m [95% CI, − to g/m ]). Doppler measures of diastolic function including peak early diastolic lateral mitral annular tissue velocity (paricalcitol group, − cm/s [95% CI, − to cm/s] vs placebo group, − cm/s [95% CI, − to cm/s]) also did not differ. Episodes of hypercalcemia were more frequent in the paricalcitol group compared with the placebo group.

Kdigo guidelines steroid resistant nephrotic syndrome

kdigo guidelines steroid resistant nephrotic syndrome

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