When prescribing acetazolamide for chronic indications, be sure to obtain a baseline complete blood count with platelets and serum electrolytes. To evaluate electrolytes, order either a sequential multiple analysis-6 (which examines carbon dioxide, chloride, creatine, potassium, sodium and urea nitrogen levels) or an electrolyte panel (which examines bicarbonate, chloride, carbon dioxide, potassium and sodium levels). Periodic retesting (., every six months) is necessary to monitor hematologic reactions and electrolyte imbalances. Finally, it is important to note that acetazolamide is highly plasma protein bound (PPB). So, monitor patients who already take PPB agents, such as oral hypoglycemic drugs, for adverse effects secondary to excessive drug levels.