Seretide combination inhaler (contains the steroid fluticasone and longacting beta agonist salmeterol) to be given through a spacer device. The darker the inhaler, the higher the dose. Left hand has 50 mcg, middle one 125 mcg and right hand 250 mcg of fluticasone per puff, whilst they all contain the same 25 mcg dose of salmeterol.
Seretide combination inhaler (contains the steroid fluticasone and long acting beta agonist salmeterol) can also be given as a dry powder in a device called an accuhaler. It comes with different fluticasone strengths - 100, 250 and 500 mcg per puff, always with salmeterol at the same dose of 50 mcg per puff, but I only use the lowest dose as a dry powder.
Symbicort combination inhaler (contains the steroid budesonide and long acting beta agonist formoterol) can only be given as a dry powder in a device called a turbohaler. It comes in different combinations – 100/6, 200/6, and 400/12; the budesonide dose is 100 or 200, the formoterol dose 6 or 12 per puff. I only use the lower dose as a dry powder.
Steroid inhalers suppress the innate immune response The body's first line of defense against intracellular and other pathogens. According to the Marshall Pathogenesis the innate immune system becomes disabled as patients develop chronic disease. , reduce immunopathology A temporary increase in disease symptoms experienced by Marshall Protocol patients that results from the release of cytokines and endotoxins as disease-causing bacteria are killed. , and delay progress for Marshall Protocol A curative medical treatment for chronic inflammatory disease. Based on the Marshall Pathogenesis. (MP) patients. For patients with obstructive lung diseases such asthma , chronic obstructive pulmonary disease, and sarcoidosis , a bronchiodilator inhaler is superior choice.
Corticosteroids have been used as drug treatment for some time. Lewis Sarett of Merck & Co. was the first to synthesize cortisone, using a complicated 36-step process that started with deoxycholic acid, which was extracted from ox bile .  The low efficiency of converting deoxycholic acid into cortisone led to a cost of US $200 per gram. Russell Marker , at Syntex , discovered a much cheaper and more convenient starting material, diosgenin from wild Mexican yams . His conversion of diosgenin into progesterone by a four-step process now known as Marker degradation was an important step in mass production of all steroidal hormones, including cortisone and chemicals used in hormonal contraception .  In 1952, . Peterson and . Murray of Upjohn developed a process that used Rhizopus mold to oxidize progesterone into a compound that was readily converted to cortisone.  The ability to cheaply synthesize large quantities of cortisone from the diosgenin in yams resulted in a rapid drop in price to US $6 per gram, falling to $ per gram by 1980. Percy Julian's research also aided progress in the field.  The exact nature of cortisone's anti-inflammatory action remained a mystery for years after, however, until the leukocyte adhesion cascade and the role of phospholipase A2 in the production of prostaglandins and leukotrienes was fully understood in the early 1980s.