Steroidogenic acute regulatory protein an update on its regulation and mechanism of action

In humans, the CYP17A1 gene is largely associated with endocrine effects and steroid hormone metabolism. [21] [22] [23] Furthermore, mutations in the CYP17A1 gene are associated with rare forms of congenital adrenal hyperplasia, in particular 17α-hydroxylase deficiency/17,20-lyase deficiency and isolated 17,20-lyase deficiency. Overall, CYP17A1 is an important target for inhibition in the treatment of prostate cancer because it produces androgen that is required for tumor cell growth. [24] [25] Currently, the FDA has approved only one CYP17A1 inhibitor, abiraterone, which contains a steroidal scaffold that is similar to the endogenous CYP17A1 substrates. Abiraterone is structurally similar to the substrates of other cytochrome P450 enzymes involved in steroidogenesis, and interference can pose a liability in terms of side effects. Using nonsteroidal scaffolds is expected to enable the design of compounds that interact more selectively with CYP17A1. [25] Potent inhibitors of the CYP17A1 enzyme provide a last line defense against ectopic androgenesis in advanced prostate cancer. [26]

Should there be any doubt, in 2014, a report (7) came out linking glyphosate to over twenty chronic diseases: “In the present study, US government databases were searched for GE crop data, glyphosate application data and disease epidemiological data. Correlation analyses were then performed on a total of 22 diseases in these time-series data sets. The Pearson correlation coefficients are highly significant (< 10–5) between glyphosate applications and hypertension (R = ), stroke (R = ), diabetes prevalence (R = ), diabetes incidence (R = ), obesity (R = ), lipoprotein metabolism disorder (R = ), Alzheimer’s (R = ), senile dementia (R = ), Parkinson’s (R = ), multiple sclerosis (R = ), autism (R = ), inflammatory bowel disease (R = ), intestinal infections (R = ), end stage renal disease (R = ), acute kidney failure (R =), cancers of the thyroid (R = ), liver (R = ), bladder (R = ), pancreas (R = ), kidney (R = ) and myeloid leukaemia (R = ). The Pearson correlation coefficients are highly significant (< 10–4) between the percentage of GE corn and soy planted in the US and hypertension (R = ), stroke (R = ), diabetes prevalence (R = ), diabetes incidence (R = ), obesity (R = ), lipoprotein metabolism disorder (R = ), Alzheimer’s (R = ), Parkinson’s (R = ), multiple sclerosis (R = ), hepatitis C (R = ), end stage renal disease (R = ), acute kidney failure (R = ), cancers of the thyroid (R = ), liver (R = ), bladder (R = ), pancreas (R = ), kidney (R = ) and myeloid leukaemia (R = ). The significance and strength of the correlations show that the effects of glyphosate and GE crops on human health should be further investigated.”

Steroidogenic acute regulatory protein an update on its regulation and mechanism of action

steroidogenic acute regulatory protein an update on its regulation and mechanism of action

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