Steroidogenic hormones

In humans, the CYP17A1 gene is largely associated with endocrine effects and steroid hormone metabolism. [21] [22] [23] Furthermore, mutations in the CYP17A1 gene are associated with rare forms of congenital adrenal hyperplasia, in particular 17α-hydroxylase deficiency/17,20-lyase deficiency and isolated 17,20-lyase deficiency. Overall, CYP17A1 is an important target for inhibition in the treatment of prostate cancer because it produces androgen that is required for tumor cell growth. [24] [25] Currently, the FDA has approved only one CYP17A1 inhibitor, abiraterone, which contains a steroidal scaffold that is similar to the endogenous CYP17A1 substrates. Abiraterone is structurally similar to the substrates of other cytochrome P450 enzymes involved in steroidogenesis, and interference can pose a liability in terms of side effects. Using nonsteroidal scaffolds is expected to enable the design of compounds that interact more selectively with CYP17A1. [25] Potent inhibitors of the CYP17A1 enzyme provide a last line defense against ectopic androgenesis in advanced prostate cancer. [26]

Should there be any doubt, in 2014, a report (7) came out linking glyphosate to over twenty chronic diseases: “In the present study, US government databases were searched for GE crop data, glyphosate application data and disease epidemiological data. Correlation analyses were then performed on a total of 22 diseases in these time-series data sets. The Pearson correlation coefficients are highly significant (< 10–5) between glyphosate applications and hypertension (R = ), stroke (R = ), diabetes prevalence (R = ), diabetes incidence (R = ), obesity (R = ), lipoprotein metabolism disorder (R = ), Alzheimer’s (R = ), senile dementia (R = ), Parkinson’s (R = ), multiple sclerosis (R = ), autism (R = ), inflammatory bowel disease (R = ), intestinal infections (R = ), end stage renal disease (R = ), acute kidney failure (R =), cancers of the thyroid (R = ), liver (R = ), bladder (R = ), pancreas (R = ), kidney (R = ) and myeloid leukaemia (R = ). The Pearson correlation coefficients are highly significant (< 10–4) between the percentage of GE corn and soy planted in the US and hypertension (R = ), stroke (R = ), diabetes prevalence (R = ), diabetes incidence (R = ), obesity (R = ), lipoprotein metabolism disorder (R = ), Alzheimer’s (R = ), Parkinson’s (R = ), multiple sclerosis (R = ), hepatitis C (R = ), end stage renal disease (R = ), acute kidney failure (R = ), cancers of the thyroid (R = ), liver (R = ), bladder (R = ), pancreas (R = ), kidney (R = ) and myeloid leukaemia (R = ). The significance and strength of the correlations show that the effects of glyphosate and GE crops on human health should be further investigated.”

Steroidogenic hormones

steroidogenic hormones

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