I don’t think that just because it doesn’t pass through the blood-brain barrier that it can’t produce a calming effect for the rest of your body. If your body feels relaxed, then it is easier for your mind to follow suit. I’ve been on GABA for about a month now. With my anxiety/OCD I generally feel like I have substances sticking to me. My muscles feel tense. But after about a month on GABA, my muscles actually feel more relaxed and the feeling of things sticking to my skin feels more subtle and goes away eventually much quicker. And I feel that because my physical body doesn’t seem to be holding on to the lingering anxiety, my mind also begins to think that it doesn’t need to be thinking about anxious thoughts. I believe that our mind and physical state is strongly connected and that even just the physical sense of calm can induce the mind to calm as well. Just like the practice of Yoga induces brain calm and not that brain calm directly induces one to do Yoga. I really do think that “placebo effect” is really an incorrect assumption in light of that.
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